TY - JOUR
KW - Antioxidants
KW - DNA damage
KW - DNA methylation
KW - diet
KW - Healthy
KW - diet
KW - Mediterranean
KW - Eating
KW - Epigenomics
KW - Female
KW - Food Analysis
KW - Gene Expression
KW - health status
KW - Humans
KW - Isothiocyanates
KW - male
KW - Mediterranean diet
KW - MicroRNAs
KW - Nutrigenetics
KW - nutrigenomics
KW - Phenylethyl Alcohol
KW - Review
KW - Xanthine
KW - alcohol consumption
KW - antiinflammatory activity
KW - antioxidant
KW - antioxidant activity
KW - apoptosis
KW - cardiovascular disease
KW - cell proliferation
KW - dietary intake
KW - drug effect
KW - Eating
KW - environmental factor
KW - epigenetics
KW - Female
KW - Food Analysis
KW - fruit
KW - Gene Expression
KW - gene frequency
KW - gene interaction
KW - genetic risk
KW - genetic variability
KW - genetic variation
KW - genetics
KW - genomic instability
KW - genotype
KW - health status
KW - histone deacetylase
KW - histone modification
KW - human
KW - hydroxytyrosol
KW - inflammasome
KW - insulin sensitivity
KW - isothiocyanic acid derivative
KW - lifestyle
KW - low density lipoprotein cholesterol
KW - male
KW - maternal nutrition
KW - metabolism
KW - microRNA
KW - microRNA 21
KW - Nutrigenetics
KW - nutrigenomics
KW - nutritional epigenetics
KW - obesity
KW - oxidative stress
KW - phenethyl alcohol
KW - physical inactivity
KW - physiology
KW - signal transduction
KW - single nucleotide polymorphism
KW - sirtuin 1
KW - soybean oil
KW - sulforafan
KW - sulforaphane
KW - telomere length
KW - transcription factor Nrf2
KW - transcriptome
KW - triacylglycerol
KW - waist circumference
KW - Xanthine
AU - F. Caradonna
AU - O. Consiglio
AU - C. Luparello
AU - C. Gentile
AB - The Mediterranean Diet (MD), UNESCO Intangible Cultural Heritage of Humanity, has become a scientific topic of high interest due to its health benefits. The aim of this review is to pick up selected studies that report nutrigenomic or nutrigenetic data and recapitulate some of the biochemical/genomic/genetic aspects involved in the positive health effects of the MD. These include (i) the antioxidative potential of its constituents with protective effects against several diseases; (ii) the epigenetic and epigenomic effects exerted by food components, such as Indacaxanthin, Sulforaphane, and 3-Hydroxytyrosol among others, and their involvement in the modulation of miRNA expression; (iii) the existence of predisposing or protective human genotypes due to allelic diversities and the impact of the MD on disease risk. A part of the review is dedicated to the nutrigenomic effects of the main cooking methods used in the MD and also to a comparative analysis of the nutrigenomic properties of the MD and other diet regimens and non-MD-related aliments. Taking all the data into account, the traditional MD emerges as a diet with a high antioxidant and nutrigenomic modulation power, which is an example of the "Environment-Livings-Environment" relationship and an excellent patchwork of interconnected biological actions working toward human health.
DO - 10.3390/nu12061748
M1 - 6
N1 - Publisher: MDPI AG
N2 - The Mediterranean Diet (MD), UNESCO Intangible Cultural Heritage of Humanity, has become a scientific topic of high interest due to its health benefits. The aim of this review is to pick up selected studies that report nutrigenomic or nutrigenetic data and recapitulate some of the biochemical/genomic/genetic aspects involved in the positive health effects of the MD. These include (i) the antioxidative potential of its constituents with protective effects against several diseases; (ii) the epigenetic and epigenomic effects exerted by food components, such as Indacaxanthin, Sulforaphane, and 3-Hydroxytyrosol among others, and their involvement in the modulation of miRNA expression; (iii) the existence of predisposing or protective human genotypes due to allelic diversities and the impact of the MD on disease risk. A part of the review is dedicated to the nutrigenomic effects of the main cooking methods used in the MD and also to a comparative analysis of the nutrigenomic properties of the MD and other diet regimens and non-MD-related aliments. Taking all the data into account, the traditional MD emerges as a diet with a high antioxidant and nutrigenomic modulation power, which is an example of the "Environment-Livings-Environment" relationship and an excellent patchwork of interconnected biological actions working toward human health.
SP - 1748
EP - 1748
TI - Science and healthy meals in the world: nutritional epigenomics and nutrigenetics of the Mediterranean diet.
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086624359&doi=10.3390%2fnu12061748&partnerID=40&md5=581f5d4061af722b63793c7b5b844556
VL - 12
SN - 20726643 (ISSN)
ER -