04449nas a2201165   4500000000100000000000100001008004100002653001700043653001500060653002000075653000900095653001200104653000900116653001800125653001100143653001600154653001100170653001800181653002000199653001800219653001100237653002000248653000900268653002300277653001400300653001800314653001800332653002400350653001100374653001300385653002400398653003000422653001600452653002500468653001400493653002700507653002300534653001900557653001600576653001100592653002500603653001600628653001100644653001800655653001000673653002000683653001900703653002100722653001700743653002400760653002200784653001300806653002400819653001300843653001800856653002400874653002500898653001000923653001900933653001700952653002400969653003400993653001401027653004001041653000901081653002301090653001501113653001301128653001601141653001801157653001801175653002801193653001201221653002101233653002201254653002401276653001501300653002401315653003501339653001401374653001601388653001501404653001701419653002001436653003001456653001801486653002001504653002401524653001301548100001701561700001701578700001701595700001501612245011301627856014301740300001401883490000701897520135901904022002003263                                       d10aAntioxidants10aDNA damage10aDNA methylation10adiet10aHealthy10adiet10aMediterranean10aEating10aEpigenomics10aFemale10aFood Analysis10aGene Expression10ahealth status10aHumans10aIsothiocyanates10amale10aMediterranean diet10aMicroRNAs10aNutrigenetics10anutrigenomics10aPhenylethyl Alcohol10aReview10aXanthine10aalcohol consumption10aantiinflammatory activity10aantioxidant10aantioxidant activity10aapoptosis10acardiovascular disease10acell proliferation10adietary intake10adrug effect10aEating10aenvironmental factor10aepigenetics10aFemale10aFood Analysis10afruit10aGene Expression10agene frequency10agene interaction10agenetic risk10agenetic variability10agenetic variation10agenetics10agenomic instability10agenotype10ahealth status10ahistone deacetylase10ahistone modification10ahuman10ahydroxytyrosol10ainflammasome10ainsulin sensitivity10aisothiocyanic acid derivative10alifestyle10alow density lipoprotein cholesterol10amale10amaternal nutrition10ametabolism10amicroRNA10amicroRNA 2110aNutrigenetics10anutrigenomics10anutritional epigenetics10aobesity10aoxidative stress10aphenethyl alcohol10aphysical inactivity10aphysiology10asignal transduction10asingle nucleotide polymorphism10asirtuin 110asoybean oil10asulforafan10asulforaphane10atelomere length10atranscription factor Nrf210atranscriptome10atriacylglycerol10awaist circumference10aXanthine1 aF. Caradonna1 aO. Consiglio1 aC. Luparello1 aC. Gentile00aScience and healthy meals in the world: nutritional epigenomics and nutrigenetics of the Mediterranean diet.  uhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85086624359&doi=10.3390%2fnu12061748&partnerID=40&md5=581f5d4061af722b63793c7b5b844556  a1748-17480 v123 aThe Mediterranean Diet (MD), UNESCO Intangible Cultural Heritage of Humanity, has become a scientific topic of high interest due to its health benefits. The aim of this review is to pick up selected studies that report nutrigenomic or nutrigenetic data and recapitulate some of the biochemical/genomic/genetic aspects involved in the positive health effects of the MD. These include (i) the antioxidative potential of its constituents with protective effects against several diseases; (ii) the epigenetic and epigenomic effects exerted by food components, such as Indacaxanthin, Sulforaphane, and 3-Hydroxytyrosol among others, and their involvement in the modulation of miRNA expression; (iii) the existence of predisposing or protective human genotypes due to allelic diversities and the impact of the MD on disease risk. A part of the review is dedicated to the nutrigenomic effects of the main cooking methods used in the MD and also to a comparative analysis of the nutrigenomic properties of the MD and other diet regimens and non-MD-related aliments. Taking all the data into account, the traditional MD emerges as a diet with a high antioxidant and nutrigenomic modulation power, which is an example of the "Environment-Livings-Environment" relationship and an excellent patchwork of interconnected biological actions working toward human health.  a20726643 (ISSN)