TY - JOUR
KW - Chronic Kidney Disease
KW - diet
KW - Mediterranean
KW - Gut Microbiota
KW - Humans
KW - Intestine
KW - Large
KW - Mediterranean diet
KW - Mediterranean diet
KW - Microbiota
KW - Renal Insufficiency
KW - Chronic
KW - Review
KW - Western Diet
KW - Western Diet
KW - antioxidant
KW - Chronic Kidney Disease
KW - chronic kidney failure
KW - diet
KW - diet therapy
KW - digestion
KW - disease association
KW - disease course
KW - dysbiosis
KW - fermentation
KW - Food
KW - Health
KW - health status
KW - human
KW - immunity
KW - intestine flora
KW - large intestine
KW - microbial community
KW - microbiology
KW - microflora
KW - priority journal
KW - prophylaxis
KW - uremic toxin
AU - Eustacchio Montemurno
AU - Carmela Cosola
AU - Giuseppe Dalfino
AU - Giuseppe Daidone
AU - Maria De Angelis
AU - Marco Gobbetti
AU - Loreto Gesualdo
AB - In this review we elucidate the role of gut microbiota as the plausible missing link between food and health, focusing on chronic kidney disease (CKD). Microbiota, the microbial community harboured in the large intestine, is considered a symbiotic "supplementary organ". It contributes to digestion, mainly through two catabolic pathways: saccharolytic (fermentation) or proteolytic (putrefaction). It also interacts with host influencing immunity, metabolism, and health status. It is believed that a balanced healthy microbiota is primarily saccharolytic and diet has a deep effect on its composition. Mediterranean Diet, UNESCO "Intangible Cultural Heritage of Humanity", prevents cardiovascular and metabolic systemic diseases, thanks to the high supply of fibres and antioxidants. Mediterranean Diet also favours the prevalence of saccharolytic species, while Western Diet promotes the shift towards a proteolytic profile (dysbiosis). Emerging evidences highlight the association between a wide range of diseases and dysbiosis. In CKD a vicious circle exists, in which proteolytic-derived microbial metabolites (p-cresol and indoxyl sulphate), represent the main circulating uremic toxins: their accumulation worsens dysbiosis and promotes CKD progression. Gut microbiota shaping through non-pharmacologic nutritional treatments, based on Mediterranean Diet, represents an innovative approach in CKD, potentially restoring microbiota balance, ameliorating CKD conditions and slowing down disease progression.
DO - 10.1159/000355785
M1 - 2
N1 - Publisher: S. Karger AG
N2 - In this review we elucidate the role of gut microbiota as the plausible missing link between food and health, focusing on chronic kidney disease (CKD). Microbiota, the microbial community harboured in the large intestine, is considered a symbiotic "supplementary organ". It contributes to digestion, mainly through two catabolic pathways: saccharolytic (fermentation) or proteolytic (putrefaction). It also interacts with host influencing immunity, metabolism, and health status. It is believed that a balanced healthy microbiota is primarily saccharolytic and diet has a deep effect on its composition. Mediterranean Diet, UNESCO "Intangible Cultural Heritage of Humanity", prevents cardiovascular and metabolic systemic diseases, thanks to the high supply of fibres and antioxidants. Mediterranean Diet also favours the prevalence of saccharolytic species, while Western Diet promotes the shift towards a proteolytic profile (dysbiosis). Emerging evidences highlight the association between a wide range of diseases and dysbiosis. In CKD a vicious circle exists, in which proteolytic-derived microbial metabolites (p-cresol and indoxyl sulphate), represent the main circulating uremic toxins: their accumulation worsens dysbiosis and promotes CKD progression. Gut microbiota shaping through non-pharmacologic nutritional treatments, based on Mediterranean Diet, represents an innovative approach in CKD, potentially restoring microbiota balance, ameliorating CKD conditions and slowing down disease progression.
SP - 114
EP - 123
TI - What Would You Like to Eat, Mr CKD Microbiota? A Mediterranean Diet, please!
UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906012965&doi=10.1159%2f000355785&partnerID=40&md5=ff21fec45da1512fe7527666ba4a5600
VL - 39
SN - 14204096 (ISSN)
ER -