03289nas a2200673   4500000000100000000000100001008004100002653002700043653000900070653001800079653001900097653001100116653001400127653001000141653002300151653002300174653001500197653002400212653001200236653001100248653001700259653001700276653001600293653002700309653002700336653000900363653001700372653001400389653002400403653001900427653001400446653001700460653000900477653001100486653001800497653001000515653001300525653002000538653002000558653002400578653001700602653001500619653002100634653001600655653001700671100002600688700001900714700002100733700002100754700002100775700001900796700002000815245008100835856014200916300001201058490000701070520151801077022002002595                                       d10aChronic Kidney Disease10adiet10aMediterranean10aGut Microbiota10aHumans10aIntestine10aLarge10aMediterranean diet10aMediterranean diet10aMicrobiota10aRenal Insufficiency10aChronic10aReview10aWestern Diet10aWestern Diet10aantioxidant10aChronic Kidney Disease10achronic kidney failure10adiet10adiet therapy10adigestion10adisease association10adisease course10adysbiosis10afermentation10aFood10aHealth10ahealth status10ahuman10aimmunity10aintestine flora10alarge intestine10amicrobial community10amicrobiology10amicroflora10apriority journal10aprophylaxis10auremic toxin1 aEustacchio Montemurno1 aCarmela Cosola1 aGiuseppe Dalfino1 aGiuseppe Daidone1 aMaria De Angelis1 aMarco Gobbetti1 aLoreto Gesualdo00aWhat Would You Like to Eat, Mr CKD Microbiota? A Mediterranean Diet, please!  uhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84906012965&doi=10.1159%2f000355785&partnerID=40&md5=ff21fec45da1512fe7527666ba4a5600  a114-1230 v393 aIn this review we elucidate the role of gut microbiota as the plausible missing link between food and health, focusing on chronic kidney disease (CKD). Microbiota, the microbial community harboured in the large intestine, is considered a symbiotic "supplementary organ". It contributes to digestion, mainly through two catabolic pathways: saccharolytic (fermentation) or proteolytic (putrefaction). It also interacts with host influencing immunity, metabolism, and health status. It is believed that a balanced healthy microbiota is primarily saccharolytic and diet has a deep effect on its composition. Mediterranean Diet, UNESCO "Intangible Cultural Heritage of Humanity", prevents cardiovascular and metabolic systemic diseases, thanks to the high supply of fibres and antioxidants. Mediterranean Diet also favours the prevalence of saccharolytic species, while Western Diet promotes the shift towards a proteolytic profile (dysbiosis). Emerging evidences highlight the association between a wide range of diseases and dysbiosis. In CKD a vicious circle exists, in which proteolytic-derived microbial metabolites (p-cresol and indoxyl sulphate), represent the main circulating uremic toxins: their accumulation worsens dysbiosis and promotes CKD progression. Gut microbiota shaping through non-pharmacologic nutritional treatments, based on Mediterranean Diet, represents an innovative approach in CKD, potentially restoring microbiota balance, ameliorating CKD conditions and slowing down disease progression.  a14204096 (ISSN)